Grace Hospital — the toughest surgical residency program west of Harvard was a brutal training ground but now former students MEREDITH, CRISTINA, IZZIE and ALEX have interns of their own to mentor. Among the new crop are GEORGE (forced to repeat his internship after failing his exams) and LEXIE GREY, Meredith’s half-sister. The doctors deal with life-or-death consequences on a daily basis — it’s in one another that they find comfort, friendship and, at times, more than friendship. Together they’re discovering that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey